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Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer

Optineurin (Optn) is a 577 aa protein encoded by the Optn gene. Mutations of Optn are associated with normal tension glaucoma and amyotrophic lateral sclerosis, and its gene has also been linked to the development of Paget’s disease of bone and Crohn’s disease. Optn is involved in diverse cellular f...

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Detalles Bibliográficos
Autores principales: Weil, Robert, Laplantine, Emmanuel, Curic, Shannel, Génin, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018216/
https://www.ncbi.nlm.nih.gov/pubmed/29971063
http://dx.doi.org/10.3389/fimmu.2018.01243