Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism

Mutations in the SHANK family of genes have been consistently identified in genetic and genomic screens of autism spectrum disorder (ASD). The functional overlap of SHANK with several other ASD-associated genes suggests synaptic dysfunction as a convergent mechanism of pathophysiology in ASD. Althou...

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Detalles Bibliográficos
Autores principales: Modi, Meera E., Brooks, Julie M., Guilmette, Edward R., Beyna, Mercedes, Graf, Radka, Reim, Dominik, Schmeisser, Michael J., Boeckers, Tobias M., O’Donnell, Patricio, Buhl, Derek L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018399/
https://www.ncbi.nlm.nih.gov/pubmed/29970986
http://dx.doi.org/10.3389/fnmol.2018.00107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018399/
https://www.ncbi.nlm.nih.gov/pubmed/29970986
http://dx.doi.org/10.3389/fnmol.2018.00107

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