Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

The human APOBEC3G protein is a cytidine deaminase that generates cytidine to deoxy-uridine mutations in single-stranded DNA (ssDNA), and capable of restricting replication of HIV-1 by generating mutations in viral genome. The mechanism by which APOBEC3G specifically deaminates 5′-CC motifs has rema...

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Detalles Bibliográficos
Autores principales: Maiti, Atanu, Myint, Wazo, Kanai, Tapan, Delviks-Frankenberry, Krista, Sierra Rodriguez, Christina, Pathak, Vinay K., Schiffer, Celia A., Matsuo, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018426/
https://www.ncbi.nlm.nih.gov/pubmed/29941968
http://dx.doi.org/10.1038/s41467-018-04872-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018426/
https://www.ncbi.nlm.nih.gov/pubmed/29941968
http://dx.doi.org/10.1038/s41467-018-04872-8

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