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Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
The human APOBEC3G protein is a cytidine deaminase that generates cytidine to deoxy-uridine mutations in single-stranded DNA (ssDNA), and capable of restricting replication of HIV-1 by generating mutations in viral genome. The mechanism by which APOBEC3G specifically deaminates 5′-CC motifs has rema...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018426/ https://www.ncbi.nlm.nih.gov/pubmed/29941968 http://dx.doi.org/10.1038/s41467-018-04872-8 |