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Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach

Recent advances in large-scale gene expression profiling necessitate concurrent development of biostatistical approaches to reveal meaningful biological relationships. Most analyses rely on significance thresholds for identifying differentially expressed genes. We use an approach to compare gene exp...

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Detalles Bibliográficos
Autores principales: Cahill, Kelly M., Huo, Zhiguang, Tseng, George C., Logan, Ryan W., Seney, Marianne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018631/
https://www.ncbi.nlm.nih.gov/pubmed/29942049
http://dx.doi.org/10.1038/s41598-018-27903-2