N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression

Accumulation of ubiquitinated protein aggregates is a common pathology associated with a number of neurodegenerative diseases and selective autophagy plays a critical role in their elimination. Although aging-related decreases in protein degradation properties may enhance protein aggregation, it rem...

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Detalles Bibliográficos
Autores principales: Matsumoto, Gen, Inobe, Tomonao, Amano, Takanori, Murai, Kiyohito, Nukina, Nobuyuki, Mori, Nozomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018635/
https://www.ncbi.nlm.nih.gov/pubmed/29941919
http://dx.doi.org/10.1038/s41598-018-27872-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018635/
https://www.ncbi.nlm.nih.gov/pubmed/29941919
http://dx.doi.org/10.1038/s41598-018-27872-6

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