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Pooled CRISPR interference screening enables genome-scale functional genomics study in bacteria with superior performance
To fully exploit the microbial genome resources, a high-throughput experimental platform is needed to associate genes with phenotypes at the genome level. We present here a novel method that enables investigation of the cellular consequences of repressing individual transcripts based on the CRISPR i...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018678/ https://www.ncbi.nlm.nih.gov/pubmed/29946130 http://dx.doi.org/10.1038/s41467-018-04899-x |