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Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation

We show that formyl benzeno boronic acids (2FBBA) selectively react with N-terminal cysteines to yield a boronated thiazolidine featuring a B–N bond. The reaction exhibits a very rapid constant rate (2.38 ± 0.23 × 10(2) M(–1) s(–1)) under mild aqueous conditions (pH 7.4, 23 °C) and tolerates differe...

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Detalles Bibliográficos
Autores principales: Faustino, Hélio, Silva, Maria J. S. A., Veiros, Luís F., Bernardes, Gonçalo J. L., Gois, Pedro M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018717/
https://www.ncbi.nlm.nih.gov/pubmed/30155155
http://dx.doi.org/10.1039/c6sc01520d