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Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation
We show that formyl benzeno boronic acids (2FBBA) selectively react with N-terminal cysteines to yield a boronated thiazolidine featuring a B–N bond. The reaction exhibits a very rapid constant rate (2.38 ± 0.23 × 10(2) M(–1) s(–1)) under mild aqueous conditions (pH 7.4, 23 °C) and tolerates differe...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018717/ https://www.ncbi.nlm.nih.gov/pubmed/30155155 http://dx.doi.org/10.1039/c6sc01520d |