miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models

Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Cerro-Herreros, Estefania, Sabater-Arcis, Maria, Fernandez-Costa, Juan M., Moreno, Nerea, Perez-Alonso, Manuel, Llamusi, Beatriz, Artero, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018771/
https://www.ncbi.nlm.nih.gov/pubmed/29946070
http://dx.doi.org/10.1038/s41467-018-04892-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018771/
https://www.ncbi.nlm.nih.gov/pubmed/29946070
http://dx.doi.org/10.1038/s41467-018-04892-4

Ejemplares similares