Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex

The core CoREST complex (LHC) contains histone deacetylase HDAC1 and histone demethylase LSD1 held together by the scaffold protein CoREST. Here, we analyze the purified LHC with modified peptide and reconstituted semisynthetic mononucleosome substrates. LHC demethylase activity toward methyl-Lys4 i...

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Detalles Bibliográficos
Autores principales: Wu, Mingxuan, Hayward, Dawn, Kalin, Jay H, Song, Yun, Schwabe, John WR, Cole, Philip A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019071/
https://www.ncbi.nlm.nih.gov/pubmed/29869982
http://dx.doi.org/10.7554/eLife.37231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019071/
https://www.ncbi.nlm.nih.gov/pubmed/29869982
http://dx.doi.org/10.7554/eLife.37231

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