1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors

We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to calcium/calmodulin-dependent protein kinase ki...

Descripción completa

Detalles Bibliográficos
Autores principales: Asquith, Christopher R. M., Godoi, Paulo H., Couñago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019134/
https://www.ncbi.nlm.nih.gov/pubmed/29783765
http://dx.doi.org/10.3390/molecules23051221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019134/
https://www.ncbi.nlm.nih.gov/pubmed/29783765
http://dx.doi.org/10.3390/molecules23051221

Ejemplares similares