Optimal dynamic regimens with artificial intelligence: The case of temozolomide

We determine an optimal protocol for temozolomide using population variability and dynamic optimization techniques inspired by artificial intelligence. We use a Pharmacokinetics/Pharmacodynamics (PK/PD) model based on Faivre and coauthors (Faivre, et al., 2013) for the pharmacokinetics of temozolomi...

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Detalles Bibliográficos
Autores principales: Houy, Nicolas, Le Grand, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019254/
https://www.ncbi.nlm.nih.gov/pubmed/29944669
http://dx.doi.org/10.1371/journal.pone.0199076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019254/
https://www.ncbi.nlm.nih.gov/pubmed/29944669
http://dx.doi.org/10.1371/journal.pone.0199076

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