Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation

We recently reported an unconventional mechanism by which miRNAs inhibit HIV-1 viral production. This occurs when miRNAs bind nonspecifically to the viral structural protein Gag, interfering with viral RNA-mediated Gag assembly at the plasma membrane. Consequently, misassembled viral complexes are r...

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Detalles Bibliográficos
Autores principales: Qu, Na, Ma, Zhao, Zhang, Mengrao, Rushdi, Muaz N., Krueger, Christopher J., Chen, Antony K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019656/
https://www.ncbi.nlm.nih.gov/pubmed/28884441
http://dx.doi.org/10.1007/s13238-017-0461-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019656/
https://www.ncbi.nlm.nih.gov/pubmed/28884441
http://dx.doi.org/10.1007/s13238-017-0461-z

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