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Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-β1 (TGF-β1)

Treatment for musculoskeletal fibromatosis remains challenging. Surgical excision for fibromatosis is the standard therapy but recurrence remains high. Corticosteroids, an anti-fibrogenic compound, have been used to treat early stage palmar fibromatosis, but the mechanism is unknown. We investigated...

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Detalles Bibliográficos
Autores principales: Wang, Jung-Pan, Yu, Hsiang-Hsuan Michael, Chiang, En-Rung, Wang, Jir-You, Chou, Po- Hsin, Hung, Shih-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019676/
https://www.ncbi.nlm.nih.gov/pubmed/29944666
http://dx.doi.org/10.1371/journal.pone.0198326