Mitochondrial translation requires folate-dependent tRNA methylation

Folates enable the activation and transfer of one-carbon units for biosynthesis of purines, thymidine and methionine(1–3). Antifolates are important immunosuppressive(4) and anticancer agents(5). In proliferating lymphocytes(6) and human cancers(7,8), folate enzymes localizing to the mitochondria ar...

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Detalles Bibliográficos
Autores principales: Morscher, Raphael J., Ducker, Gregory S., Li, Sophia Hsin-Jung, Mayer, Johannes A., Gitai, Zemer, Sperl, Wolfgang, Rabinowitz, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020024/
https://www.ncbi.nlm.nih.gov/pubmed/29364879
http://dx.doi.org/10.1038/nature25460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020024/
https://www.ncbi.nlm.nih.gov/pubmed/29364879
http://dx.doi.org/10.1038/nature25460

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