Cargando…
Mitochondrial translation requires folate-dependent tRNA methylation
Folates enable the activation and transfer of one-carbon units for biosynthesis of purines, thymidine and methionine(1–3). Antifolates are important immunosuppressive(4) and anticancer agents(5). In proliferating lymphocytes(6) and human cancers(7,8), folate enzymes localizing to the mitochondria ar...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020024/ https://www.ncbi.nlm.nih.gov/pubmed/29364879 http://dx.doi.org/10.1038/nature25460 |