Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody

Sclerostin antibody (Scl-Ab) stimulates bone formation, which with long-term treatment, attenuates over time. The cellular and molecular mechanisms responsible for the attenuation of bone formation are not well understood, but in aged ovariectomized (OVX) rats, the reduction in vertebral cancellous...

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Detalles Bibliográficos
Autores principales: Boyce, Rogely Waite, Brown, Danielle, Felx, Melanie, Mellal, Nacera, Locher, Kathrin, Pyrah, Ian, Ominsky, Michael S., Taylor, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020110/
https://www.ncbi.nlm.nih.gov/pubmed/29955626
http://dx.doi.org/10.1016/j.bonr.2018.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020110/
https://www.ncbi.nlm.nih.gov/pubmed/29955626
http://dx.doi.org/10.1016/j.bonr.2018.03.001

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