Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats

Inhibition of sclerostin with sclerostin antibody (Scl-Ab) results in stimulation of bone formation on cancellous (Cn), endocortical (Ec), and periosteal (Ps) surfaces in rodents and non-human primates. With long-term dosing of Scl-Ab, the increase in bone formation is not sustained, attenuating fir...

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Detalles Bibliográficos
Autores principales: Taylor, Scott, Hu, Rong, Pacheco, Efrain, Locher, Kathrin, Pyrah, Ian, Ominsky, Michael S., Boyce, Rogely Waite
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020117/
https://www.ncbi.nlm.nih.gov/pubmed/29955627
http://dx.doi.org/10.1016/j.bonr.2018.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020117/
https://www.ncbi.nlm.nih.gov/pubmed/29955627
http://dx.doi.org/10.1016/j.bonr.2018.03.002

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