Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling

BACKGROUND: Serum and glucocorticoid-regulated kinase 3 (SGK3) has been reported to play an important role in tumour progression, but its role in cancer stem cells (CSCs) remains obscure. The phosphoinositide 3-kinase (PI3K) pathway is considered a hallmark of cancer. Although many PI3K pathway-targ...

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Detalles Bibliográficos
Autores principales: Liu, Fengchao, Wu, Xiaoling, Jiang, Xin, Qian, Yanzhi, Gao, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020243/
https://www.ncbi.nlm.nih.gov/pubmed/29940988
http://dx.doi.org/10.1186/s13046-018-0801-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020243/
https://www.ncbi.nlm.nih.gov/pubmed/29940988
http://dx.doi.org/10.1186/s13046-018-0801-8

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