Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway

We first applied moderate fluid shear stress to nucleus pulposus cells. The correlation of AP-1 with type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 and the correlation of AP-1 with IL-1β, TNF-α, IL-6, IL-8, MIP-1, MCP-1, and NO were detected. Our results document that...

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Detalles Bibliográficos
Autores principales: Ye, Dongping, Liang, Weiguo, Dai, Libing, Yao, Yicun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020454/
https://www.ncbi.nlm.nih.gov/pubmed/30008976
http://dx.doi.org/10.1155/2018/9405738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020454/
https://www.ncbi.nlm.nih.gov/pubmed/30008976
http://dx.doi.org/10.1155/2018/9405738

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