Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy

Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K(+)/Cl(−) co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic inhibition and deficits in its activity are obser...

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Detalles Bibliográficos
Autores principales: Kelley, Matt R., Cardarelli, Ross A., Smalley, Joshua L., Ollerhead, Thomas A., Andrew, Peter M., Brandon, Nicholas J., Deeb, Tarek Z., Moss, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020795/
https://www.ncbi.nlm.nih.gov/pubmed/29884458
http://dx.doi.org/10.1016/j.ebiom.2018.05.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020795/
https://www.ncbi.nlm.nih.gov/pubmed/29884458
http://dx.doi.org/10.1016/j.ebiom.2018.05.029

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