Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency

A series of nine compounds based on 3-[4-(benzyloxy)phenyl]propanoic acid core containing a 1-oxa-9-azaspiro[5.5]undecane periphery was designed, synthesized and evaluated as free fatty acid 1 (FFA1 or GPR40) agonists. The spirocyclic appendages included in these compounds were inspired by LY2881835...

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Detalles Bibliográficos
Autores principales: Krasavin, Mikhail, Lukin, Alexey, Bagnyukova, Daria, Zhurilo, Nikolay, Zahanich, Ihor, Zozulya, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021034/
https://www.ncbi.nlm.nih.gov/pubmed/27781494
http://dx.doi.org/10.1080/14756366.2016.1230110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021034/
https://www.ncbi.nlm.nih.gov/pubmed/27781494
http://dx.doi.org/10.1080/14756366.2016.1230110

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