Development of a high-throughput assay to detect antibody inhibition of low pH induced conformational changes of influenza virus hemagglutinin

Many broadly neutralizing antibodies (bnAbs) bind to conserved areas of the hemagglutinin (HA) stalk region and can inhibit the low pH induced HA conformational changes necessary for viral membrane fusion activity. We developed and evaluated a high-throughput virus-free and cell-free ELISA based low...

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Detalles Bibliográficos
Autores principales: Trost, Jessica F., LeMasters, Elizabeth H., Liu, Feng, Carney, Paul, Lu, Xiuhua, Sugawara, Kanetsu, Hongo, Seiji, Stevens, James, Steinhauer, David A., Tumpey, Terrence, Katz, Jacqueline M., Levine, Min Z., Li, Zhu-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021090/
https://www.ncbi.nlm.nih.gov/pubmed/29949635
http://dx.doi.org/10.1371/journal.pone.0199683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021090/
https://www.ncbi.nlm.nih.gov/pubmed/29949635
http://dx.doi.org/10.1371/journal.pone.0199683

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