Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis

The murine leukaemia virus (MLV) Gag cleavage product, p12, is essential for both early and late steps in viral replication. The N-terminal domain of p12 binds directly to capsid (CA) and stabilises the mature viral core, whereas defects in the C-terminal domain (CTD) of p12 can be rescued by additi...

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Detalles Bibliográficos
Autores principales: Wanaguru, Madushi, Barry, David J., Benton, Donald J., O’Reilly, Nicola J., Bishop, Kate N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021111/
https://www.ncbi.nlm.nih.gov/pubmed/29906285
http://dx.doi.org/10.1371/journal.ppat.1007117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021111/
https://www.ncbi.nlm.nih.gov/pubmed/29906285
http://dx.doi.org/10.1371/journal.ppat.1007117

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