Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice

Acute ischemic stroke (AIS) is caused by clotting in the cerebral arteries, leading to brain oxygen deprivation and cerebral infarction. Recombinant human tissue plasminogen activator (tPA) is currently the only Food and Drug Administration-approved drug for ischemic stroke. However, tPA has to be a...

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Detalles Bibliográficos
Autores principales: Chen, Shanyan, Chen, Zhenzhou, Cui, Jiankun, McCrary, Myah L., Song, Hailong, Mobashery, Shahriar, Chang, Mayland, Gu, Zezong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021166/
https://www.ncbi.nlm.nih.gov/pubmed/29963617
http://dx.doi.org/10.1523/ENEURO.0391-17.2018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021166/
https://www.ncbi.nlm.nih.gov/pubmed/29963617
http://dx.doi.org/10.1523/ENEURO.0391-17.2018

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