Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the mevalonate pathway in osteoclasts, the mechanism by which N-BPs enter the cytosol...

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Detalles Bibliográficos
Autores principales: Yu, Zhou, Surface, Lauren E, Park, Chong Yon, Horlbeck, Max A, Wyant, Gregory A, Abu-Remaileh, Monther, Peterson, Timothy R, Sabatini, David M, Weissman, Jonathan S, O'Shea, Erin K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021172/
https://www.ncbi.nlm.nih.gov/pubmed/29745899
http://dx.doi.org/10.7554/eLife.36620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021172/
https://www.ncbi.nlm.nih.gov/pubmed/29745899
http://dx.doi.org/10.7554/eLife.36620

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