Cargando…
The rabbit as an orthologous small animal model for APOBEC3A oncogenesis
APOBEC3 are cytidine deaminases that convert cytidine to uridine residues. APOBEC3A and APOBEC3B enzymes able to target genomic DNA are involved in oncogenesis of a sizeable proportion of human cancers. While the APOBEC3 locus is conserved in mammals, it encodes from 1–7 genes. APOBEC3A is conserved...
Autores principales: | Laude, Hélène C., Caval, Vincent, Bouzidi, Mohamed S., Li, Xiongxiong, Jamet, Florence, Henry, Michel, Suspène, Rodolphe, Wain-Hobson, Simon, Vartanian, Jean-Pierre |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021247/ https://www.ncbi.nlm.nih.gov/pubmed/29963239 http://dx.doi.org/10.18632/oncotarget.25593 |
Ejemplares similares
-
Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage
por: Suspène, Rodolphe, et al.
Publicado: (2017) -
Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme
por: Caval, Vincent, et al.
Publicado: (2015) -
Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics
por: Suspène, R, et al.
Publicado: (2014) -
Genotoxic stress increases cytoplasmic mitochondrial DNA editing by human APOBEC3 mutator enzymes at a single cell level
por: Mussil, Bianka, et al.
Publicado: (2019) -
Elephant APOBEC3A cytidine deaminase induces massive double-stranded DNA breaks and apoptosis
por: Li, Xiongxiong, et al.
Publicado: (2019)