The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells

Highly glycolytic tumor cells release vast amounts of lactate and protons via monocarboxylate transporters (MCTs), which exacerbate extracellular acidification and support the formation of a hostile environment. Transport activity of MCTs can be facilitated by non-catalytic interaction with carbonic...

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Detalles Bibliográficos
Autores principales: Ames, Samantha, Pastorekova, Silvia, Becker, Holger M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021347/
https://www.ncbi.nlm.nih.gov/pubmed/29963253
http://dx.doi.org/10.18632/oncotarget.25371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021347/
https://www.ncbi.nlm.nih.gov/pubmed/29963253
http://dx.doi.org/10.18632/oncotarget.25371

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