Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition

To date, the molecular mechanism underlying constitutive signal transducer and activator of transcription 3 (STAT3) activation in gliomas is largely unclear. In this study, we report that Smad6 is overexpressed in nuclei of glioma cells, which correlates with poor patient survival and regulates STAT...

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Detalles Bibliográficos
Autores principales: Jiao, Jiantong, Zhang, Rui, Li, Zheng, Yin, Ying, Fang, Xiangming, Ding, Xiaopeng, Cai, Ying, Yang, Shudong, Mu, Huijun, Zong, Da, Chen, Yuexin, Zhang, Yansong, Zou, Jian, Shao, Junfei, Huang, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021382/
https://www.ncbi.nlm.nih.gov/pubmed/29950561
http://dx.doi.org/10.1038/s41467-018-04936-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021382/
https://www.ncbi.nlm.nih.gov/pubmed/29950561
http://dx.doi.org/10.1038/s41467-018-04936-9

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