Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition

To date, the molecular mechanism underlying constitutive signal transducer and activator of transcription 3 (STAT3) activation in gliomas is largely unclear. In this study, we report that Smad6 is overexpressed in nuclei of glioma cells, which correlates with poor patient survival and regulates STAT...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiao, Jiantong, Zhang, Rui, Li, Zheng, Yin, Ying, Fang, Xiangming, Ding, Xiaopeng, Cai, Ying, Yang, Shudong, Mu, Huijun, Zong, Da, Chen, Yuexin, Zhang, Yansong, Zou, Jian, Shao, Junfei, Huang, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021382/
https://www.ncbi.nlm.nih.gov/pubmed/29950561
http://dx.doi.org/10.1038/s41467-018-04936-9

Ejemplares similares

Ejemplares similares