The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice

Zinc (Zn(2+)) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn(2+) levels triggers neurotoxic processes and affects neuronal functioning. In this study, we investigated how the pharmacological modulation of brain Zn(2+) affects synaptic plasticity and...

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Detalles Bibliográficos
Autores principales: Frazzini, Valerio, Granzotto, Alberto, Bomba, Manuela, Massetti, Noemi, Castelli, Vanessa, d’Aurora, Marco, Punzi, Miriam, Iorio, Mariangela, Mosca, Alessandra, Delli Pizzi, Stefano, Gatta, Valentina, Cimini, Annamaria, Sensi, Stefano L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021411/
https://www.ncbi.nlm.nih.gov/pubmed/29950603
http://dx.doi.org/10.1038/s41598-018-28083-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021411/
https://www.ncbi.nlm.nih.gov/pubmed/29950603
http://dx.doi.org/10.1038/s41598-018-28083-9

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