C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains

To investigate the fidelity of canonical non-homologous end joining (C-NHEJ), we developed an assay to detect EJ between distal ends of two Cas9-induced chromosomal breaks that are joined without causing insertion/deletion mutations (indels). Here we find that such EJ requires several core C-NHEJ fa...

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Detalles Bibliográficos
Autores principales: Bhargava, Ragini, Sandhu, Manbir, Muk, Sanychen, Lee, Gabriella, Vaidehi, Nagarajan, Stark, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021437/
https://www.ncbi.nlm.nih.gov/pubmed/29950655
http://dx.doi.org/10.1038/s41467-018-04867-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021437/
https://www.ncbi.nlm.nih.gov/pubmed/29950655
http://dx.doi.org/10.1038/s41467-018-04867-5

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