Structural basis of the correct subunit assembly, aggregation, and intracellular degradation of nylon hydrolase

Nylon hydrolase (NylC) is initially expressed as an inactive precursor (36 kDa). The precursor is cleaved autocatalytically at Asn266/Thr267 to generate an active enzyme composed of an α subunit (27 kDa) and a β subunit (9 kDa). Four αβ heterodimers (molecules A-D) form a doughnut-shaped quaternary...

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Detalles Bibliográficos
Autores principales: Negoro, Seiji, Shibata, Naoki, Lee, Young-Ho, Takehara, Ikki, Kinugasa, Ryo, Nagai, Keisuke, Tanaka, Yusuke, Kato, Dai-ichiro, Takeo, Masahiro, Goto, Yuji, Higuchi, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021441/
https://www.ncbi.nlm.nih.gov/pubmed/29950566
http://dx.doi.org/10.1038/s41598-018-27860-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021441/
https://www.ncbi.nlm.nih.gov/pubmed/29950566
http://dx.doi.org/10.1038/s41598-018-27860-w

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