Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm

Polymyxin B is used as an antibiotic of last resort for patients with multidrug-resistant Gram-negative bacterial infections; however, it carries a significant risk of nephrotoxicity. Herein we present a polymyxin B therapeutic window based on target area under the concentration-time curve (AUC) val...

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Detalles Bibliográficos
Autores principales: Lakota, Elizabeth A., Landersdorfer, Cornelia B., Nation, Roger L., Li, Jian, Kaye, Keith S., Rao, Gauri G., Forrest, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021635/
https://www.ncbi.nlm.nih.gov/pubmed/29760144
http://dx.doi.org/10.1128/AAC.00483-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021635/
https://www.ncbi.nlm.nih.gov/pubmed/29760144
http://dx.doi.org/10.1128/AAC.00483-18

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