Anti-colchicine Fab fragments prevent lethal colchicine toxicity in a porcine model: a pharmacokinetic and clinical study

Background: Colchicine poisoning is commonly lethal. Colchicine-specific Fab fragments increase rat urinary colchicine clearance and have been associated with a good outcome in one patient. We aimed to develop a porcine model of colchicine toxicity to study the pharmacokinetics and efficacy of ovine...

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Detalles Bibliográficos
Autores principales: Eddleston, Michael, Fabresse, Nicolas, Thompson, Adrian, Al Abdulla, Ibrahim, Gregson, Rachael, King, Tim, Astier, Alain, Baud, Frederic J., Clutton, R Eddie, Alvarez, Jean-Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021765/
https://www.ncbi.nlm.nih.gov/pubmed/29334816
http://dx.doi.org/10.1080/15563650.2017.1422510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021765/
https://www.ncbi.nlm.nih.gov/pubmed/29334816
http://dx.doi.org/10.1080/15563650.2017.1422510

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