Mechanistic elucidation guided by covalent inhibitors for the development of anti-diabetic PPARγ ligands

Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-regulated transcription factor that plays crucial roles in adipogenesis, lipid metabolism, and glucose homeostasis. Several PPARγ ligands possess anti-diabetic activity and they commonly inhibit the phosphorylation of PPARγ at seri...

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Detalles Bibliográficos
Autores principales: Bae, Hwan, Jang, Jun Young, Choi, Sun-Sil, Lee, Jae-Jin, Kim, Heejun, Jo, Ala, Lee, Kong-Joo, Choi, Jang Hyun, Suh, Se Won, Park, Seung Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021786/
https://www.ncbi.nlm.nih.gov/pubmed/30034693
http://dx.doi.org/10.1039/c6sc01279e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021786/
https://www.ncbi.nlm.nih.gov/pubmed/30034693
http://dx.doi.org/10.1039/c6sc01279e

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