A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma

Indoleamine 2,3-dioxygenase 1 (IDO1) activity links to immune escape of cancers. Inhibition of IDO1 provides a new approach for cancer treatment. Most clinical IDO1 drugs show marginal efficacy as single agents. On basis of molecular docking and pharmacophore modelling, a novel inhibitor Roxyl-WL wa...

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Detalles Bibliográficos
Autores principales: Xu, Guangwei, Wang, Tianqi, Li, Yongtao, Huang, Zhi, Wang, Xin, Zheng, Jianyu, Yang, Shengyong, Fan, Yan, Xiang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022239/
https://www.ncbi.nlm.nih.gov/pubmed/29932010
http://dx.doi.org/10.1080/14756366.2018.1471688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022239/
https://www.ncbi.nlm.nih.gov/pubmed/29932010
http://dx.doi.org/10.1080/14756366.2018.1471688

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