STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4(+) T Cells of Patients with Colorectal Cancer

The tumor-infiltrating Tregs are linked to colorectal cancer progression and outcome. FOXP3 is regarded as a critical developmental and functional factor for Tregs. FOXP3-TSDR demethylation is required for stable expression of FOXP3 and maintenance of Treg function. In our study, we found specific D...

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Detalles Bibliográficos
Autores principales: Ma, Hulin, Gao, Weishi, Sun, Xiaoxia, Wang, Weixing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022275/
https://www.ncbi.nlm.nih.gov/pubmed/30013992
http://dx.doi.org/10.1155/2018/6985031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022275/
https://www.ncbi.nlm.nih.gov/pubmed/30013992
http://dx.doi.org/10.1155/2018/6985031

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