Cargando…

STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4(+) T Cells of Patients with Colorectal Cancer

The tumor-infiltrating Tregs are linked to colorectal cancer progression and outcome. FOXP3 is regarded as a critical developmental and functional factor for Tregs. FOXP3-TSDR demethylation is required for stable expression of FOXP3 and maintenance of Treg function. In our study, we found specific D...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Hulin, Gao, Weishi, Sun, Xiaoxia, Wang, Weixing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022275/ https://www.ncbi.nlm.nih.gov/pubmed/30013992 http://dx.doi.org/10.1155/2018/6985031

Ejemplares similares

Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and TSDR demethylation
por: Khosravi, Maryam, et al.
Publicado: (2018)

Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival
por: Zhuo, Changhua, et al.
Publicado: (2014)

Demethylation of the TSDR Is a Marker of Squamous Cell Carcinoma in Transplant Recipients
por: Sherston, S N, et al.
Publicado: (2014)

FOXP3 TSDR Measurement Could Assist Variant Classification and Diagnosis of IPEX Syndrome
por: Wyatt, Rebecca C., et al.
Publicado: (2023)

Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype
por: Kressler, Christopher, et al.
Publicado: (2021)

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation
por: Someya, Kazue, et al.
Publicado: (2017)

CD45RA Distinguishes CD4+CD25+CD127−/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression
por: Arroyo Hornero, Rebeca, et al.
Publicado: (2017)

HTLV-1 epigenetic modification of the FoxP3 TSDR in HAM/TSP decreases the functional proliferative suppression of Tregs
por: Anderson, Monique R, et al.
Publicado: (2014)

Methylation of FOXP3 TSDR Underlies the Impaired Suppressive Function of Tregs from Long-term Belatacept-Treated Kidney Transplant Patients
por: Alvarez Salazar, Evelyn Katy, et al.
Publicado: (2017)

TET proteins and the control of cytosine demethylation in cancer
por: Scourzic, Laurianne, et al.
Publicado: (2015)

Helios expression and Foxp3 TSDR methylation of IFNy+ and IFNy- Treg from kidney transplant recipients with good long-term graft function
por: Trojan, Karina, et al.
Publicado: (2017)

Correction: Helios expression and Foxp3 TSDR methylation of IFNy+ and IFNy- Treg from kidney transplant recipients with good long-term graft function
por: Trojan, Karina, et al.
Publicado: (2017)

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity
por: Ferreira, Ricardo C., et al.
Publicado: (2017)

Molecular Markers Distinguishing T Cell Subtypes With TSDR Strand-Bias Methylation
por: Minskaia, Ekaterina, et al.
Publicado: (2018)

TET family dioxygenases and DNA demethylation in stem cells and cancers
por: An, Jungeun, et al.
Publicado: (2017)

TET2 coactivates gene expression through demethylation of enhancers
por: Wang, Lu, et al.
Publicado: (2018)

HMGB1 Recruits TET2/AID/TDG to Induce DNA Demethylation in STAT3 Promoter in CD4(+) T Cells from aGVHD Patients
por: Xu, Xuejun, et al.
Publicado: (2020)

Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis
por: Ma, Liyang, et al.
Publicado: (2022)

All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells
por: Sun, Xiaohong, et al.
Publicado: (2018)

Inhibition of Tet1- and Tet2-mediated DNA demethylation promotes immunomodulation of periodontal ligament stem cells
por: Yu, Tingting, et al.
Publicado: (2019)

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation
por: Zebley, Caitlin C., et al.
Publicado: (2021)

TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation
por: Stolz, Paul, et al.
Publicado: (2022)

Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter
por: Yang, Ruili, et al.
Publicado: (2018)

Control of Foxp3 stability through modulation of TET activity
por: Yue, Xiaojing, et al.
Publicado: (2016)

Targeted DNA demethylation of the Arabidopsis genome using the SunTag-dCpf1-TET1cd system
por: Zheng, Yunxi, et al.
Publicado: (2023)

Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells
por: Onodera, Atsushi, et al.
Publicado: (2021)

Vitamin C boosts DNA demethylation in TET2 germline mutation carriers
por: Taira, Aurora, et al.
Publicado: (2023)

FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans
por: Janson, Peter C. J., et al.
Publicado: (2008)

Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress
por: Xin, Yong-Juan, et al.
Publicado: (2015)

DNA Methylation and Demethylation Are Regulated by Functional DNA Methyltransferases and DnTET Enzymes in Diuraphis noxia
por: du Preez, Pieter H., et al.
Publicado: (2020)

Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development
por: Xu, Qin, et al.
Publicado: (2022)

ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation
por: Tanaka, Toru, et al.
Publicado: (2018)

TET1 inhibits gastric cancer growth and metastasis by PTEN demethylation and re-expression
por: Pei, Yao-fei, et al.
Publicado: (2016)

Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain
por: Gallego-Bartolomé, Javier, et al.
Publicado: (2018)

Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate
por: Sardina, Jose Luis, et al.
Publicado: (2018)

TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression
por: Okashita, Naoki, et al.
Publicado: (2019)

ERRATUM: Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress
por: Xin, Yong-Juan, et al.
Publicado: (2015)

Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA
por: Banks, Kelly M., et al.
Publicado: (2021)

T Regulatory Cells in Cord Blood—FOXP3 Demethylation as Reliable Quantitative Marker
por: Liu, Jing, et al.
Publicado: (2010)

Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation
por: Li, Jun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rsaslrtpfuehpbnl0an5m77am5