A new method for constructing tumor specific gene co-expression networks based on samples with tumor purity heterogeneity

MOTIVATION: Tumor tissue samples often contain an unknown fraction of stromal cells. This problem is widely known as tumor purity heterogeneity (TPH) was recently recognized as a severe issue in omics studies. Specifically, if TPH is ignored when inferring co-expression networks, edges are likely to...

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Detalles Bibliográficos
Autores principales: Petralia, Francesca, Wang, Li, Peng, Jie, Yan, Arthur, Zhu, Jun, Wang, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Ismb 2018–Intelligent Systems for Molecular Biology Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022554/
https://www.ncbi.nlm.nih.gov/pubmed/29949994
http://dx.doi.org/10.1093/bioinformatics/bty280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022554/
https://www.ncbi.nlm.nih.gov/pubmed/29949994
http://dx.doi.org/10.1093/bioinformatics/bty280

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