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A new method for constructing tumor specific gene co-expression networks based on samples with tumor purity heterogeneity
MOTIVATION: Tumor tissue samples often contain an unknown fraction of stromal cells. This problem is widely known as tumor purity heterogeneity (TPH) was recently recognized as a severe issue in omics studies. Specifically, if TPH is ignored when inferring co-expression networks, edges are likely to...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022554/ https://www.ncbi.nlm.nih.gov/pubmed/29949994 http://dx.doi.org/10.1093/bioinformatics/bty280 |