A graph-based approach to diploid genome assembly

MOTIVATION: Constructing high-quality haplotype-resolved de novo assemblies of diploid genomes is important for revealing the full extent of structural variation and its role in health and disease. Current assembly approaches often collapse the two sequences into one haploid consensus sequence and,...

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Detalles Bibliográficos
Autores principales: Garg, Shilpa, Rautiainen, Mikko, Novak, Adam M, Garrison, Erik, Durbin, Richard, Marschall, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Ismb 2018–Intelligent Systems for Molecular Biology Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022571/
https://www.ncbi.nlm.nih.gov/pubmed/29949989
http://dx.doi.org/10.1093/bioinformatics/bty279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022571/
https://www.ncbi.nlm.nih.gov/pubmed/29949989
http://dx.doi.org/10.1093/bioinformatics/bty279

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