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Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury

Dendrite pathology and synapse disassembly are critical features of chronic neurodegenerative diseases. In spite of this, the capacity of injured neurons to regenerate dendrites has been largely ignored. Here, we show that, upon axonal injury, retinal ganglion cells undergo rapid dendritic retractio...

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Detalles Bibliográficos
Autores principales: Agostinone, Jessica, Alarcon-Martinez, Luis, Gamlin, Clare, Yu, Wan-Qing, Wong, Rachel O L, Di Polo, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022605/
https://www.ncbi.nlm.nih.gov/pubmed/29931057
http://dx.doi.org/10.1093/brain/awy142