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Viral quasispecies reconstruction via tensor factorization with successive read removal

MOTIVATION: As RNA viruses mutate and adapt to environmental changes, often developing resistance to anti-viral vaccines and drugs, they form an ensemble of viral strains––a viral quasispecies. While high-throughput sequencing (HTS) has enabled in-depth studies of viral quasispecies, sequencing erro...

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Detalles Bibliográficos
Autores principales: Ahn, Soyeon, Ke, Ziqi, Vikalo, Haris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022648/
https://www.ncbi.nlm.nih.gov/pubmed/29949976
http://dx.doi.org/10.1093/bioinformatics/bty291