Small-Molecule Positive Allosteric Modulators of the β(2)-Adrenoceptor Isolated from DNA-Encoded Libraries

Conventional drug discovery efforts at the β(2)-adrenoceptor (β(2)AR) have led to the development of ligands that bind almost exclusively to the receptor’s hormone-binding orthosteric site. However, targeting the largely unexplored and evolutionarily unique allosteric sites has potential for develop...

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Detalles Bibliográficos
Autores principales: Ahn, Seungkirl, Pani, Biswaranjan, Kahsai, Alem W., Olsen, Eva K., Husemoen, Gitte, Vestergaard, Mikkel, Jin, Lei, Zhao, Shuai, Wingler, Laura M., Rambarat, Paula K., Simhal, Rishabh K., Xu, Thomas T., Sun, Lillian D., Shim, Paul J., Staus, Dean P., Huang, Li-Yin, Franch, Thomas, Chen, Xin, Lefkowitz, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022804/
https://www.ncbi.nlm.nih.gov/pubmed/29769246
http://dx.doi.org/10.1124/mol.118.111948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022804/
https://www.ncbi.nlm.nih.gov/pubmed/29769246
http://dx.doi.org/10.1124/mol.118.111948

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