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Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer

Estrogen therapy was used to treat advanced breast cancer in postmenopausal women for decades until the introduction of tamoxifen. Resistance to long-term estrogen deprivation (LTED) with tamoxifen and aromatase inhibitors used as a treatment of breast cancer inevitably occurs, but unexpectedly low-...

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Detalles Bibliográficos
Autores principales: Maximov, Philipp Y., Abderrahman, Balkees, Fanning, Sean W., Sengupta, Surojeet, Fan, Ping, Curpan, Ramona F., Rincon, Daniela Maria Quintana, Greenland, Jeffery A., Rajan, Shyamala S., Greene, Geoffrey L., Jordan, V. Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022805/
https://www.ncbi.nlm.nih.gov/pubmed/29739819
http://dx.doi.org/10.1124/mol.117.111385