Cargando…

Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer

Estrogen therapy was used to treat advanced breast cancer in postmenopausal women for decades until the introduction of tamoxifen. Resistance to long-term estrogen deprivation (LTED) with tamoxifen and aromatase inhibitors used as a treatment of breast cancer inevitably occurs, but unexpectedly low-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maximov, Philipp Y., Abderrahman, Balkees, Fanning, Sean W., Sengupta, Surojeet, Fan, Ping, Curpan, Ramona F., Rincon, Daniela Maria Quintana, Greenland, Jeffery A., Rajan, Shyamala S., Greene, Geoffrey L., Jordan, V. Craig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022805/ https://www.ncbi.nlm.nih.gov/pubmed/29739819 http://dx.doi.org/10.1124/mol.117.111385

Ejemplares similares

Influence of the Length and Positioning of the Antiestrogenic Side Chain of Endoxifen and 4-Hydroxytamoxifen on Gene Activation and Growth of Estrogen Receptor Positive Cancer Cells
por: Maximov, Philipp Y., et al.
Publicado: (2014)

Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer
por: Maximov, Philipp Y., et al.
Publicado: (2022)

The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer Cells
por: Maximov, Philipp Y., et al.
Publicado: (2020)

Pharmacology and Molecular Mechanisms of Clinically Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for the Treatment of Endocrine-Resistant Breast Cancer
por: Abderrahman, Balkees, et al.
Publicado: (2020)

Transporting Antitumor Drug Tamoxifen and Its Metabolites, 4-Hydroxytamoxifen and Endoxifen by Chitosan Nanoparticles
por: Agudelo, Daniel, et al.
Publicado: (2013)

A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers
por: Maximov, Philipp Y, et al.
Publicado: (2017)

Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen
por: Wu, Xianglin, et al.
Publicado: (2011)

Endoxifen and fulvestrant regulate estrogen-receptor α and related DEADbox proteins
por: Asberger, Jasmin, et al.
Publicado: (2020)

Importance of highly selective LC–MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen
por: Jager, N. G. L., et al.
Publicado: (2012)

Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens
por: Hawse, John R., et al.
Publicado: (2013)

Targeting Estrogen Receptor-Positive Breast Microtumors with Endoxifen-Conjugated, Hypoxia-Sensitive Polymersomes
por: Mamnoon, Babak, et al.
Publicado: (2021)

Sensitization of estrogen receptor-positive breast cancer cell lines to 4-hydroxytamoxifen by isothiocyanates present in cruciferous plants
por: Pawlik, Anna, et al.
Publicado: (2015)

Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold
por: Keely, Niall O., et al.
Publicado: (2016)

Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer
por: Jayaraman, Swaathi, et al.
Publicado: (2020)

The Discovery and Development of Selective Estrogen Receptor Modulators (SERMs) for Clinical Practice
por: Maximov, Philipp Y, et al.
Publicado: (2013)

Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation
por: Kelly, Patrick M., et al.
Publicado: (2017)

Acetyl-CoA synthetases ACSS1 and ACSS2 are 4-hydroxytamoxifen responsive factors that promote survival in tamoxifen treated and estrogen deprived cells
por: Calhoun, Sarah, et al.
Publicado: (2022)

THU554 Unconventional Estrogen Receptor Antagonists Reveal Cryptic Therapeutic Anti-breast Cancer Transcriptional Pathways
por: Hancock, Govinda, et al.
Publicado: (2023)

On the Mechanism of Membrane Permeabilization by Tamoxifen and 4-Hydroxytamoxifen
por: Ortiz, Julia, et al.
Publicado: (2023)

Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes
por: Ransom, Ryan C., et al.
Publicado: (2018)

Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancer
por: Blanchard, Zannel, et al.
Publicado: (2019)

Early career interview: Balkees Abderrahman
por: Abderrahman, Balkees
Publicado: (2020)

Mechanisms underlying differential response to estrogen-induced apoptosis in long-term estrogen-deprived breast cancer cells
por: SWEENEY, ELIZABETH E., et al.
Publicado: (2014)

Good Estrogen Bad Estrogen
por: Barrett, JR
Publicado: (2000)

Regulated control of virus replication by 4-hydroxytamoxifen-induced splicing
por: Zhao, Zhenghao, et al.
Publicado: (2023)

Endoxifen, a New Treatment Option for Mania: A Double‐Blind, Active‐Controlled Trial Demonstrates the Antimanic Efficacy of Endoxifen
por: Ahmad, A, et al.
Publicado: (2016)

Estrogen, Estrogen Receptor and Lung Cancer
por: Hsu, Li-Han, et al.
Publicado: (2017)

Estrogen and estrogen receptors in kidney diseases
por: Ma, Hao-Yang, et al.
Publicado: (2021)

Interactions of dietary estrogens with human estrogen receptors and the effect on estrogen receptor-estrogen response element complex formation.
por: Nikov, G N, et al.
Publicado: (2000)

Author Correction: Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes
por: Ransom, Ryan C., et al.
Publicado: (2018)

The Dynamic Structure of the Estrogen Receptor
por: Kumar, Raj, et al.
Publicado: (2011)

Molecular mechanism of estrogen–estrogen receptor signaling
por: Yaşar, Pelin, et al.
Publicado: (2016)

CYP2D6 genotype- and endoxifen-guided tamoxifen dose escalation increases endoxifen serum concentrations without increasing side effects
por: Dezentjé, V. O., et al.
Publicado: (2015)

The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy
por: Iorga, Andrea, et al.
Publicado: (2017)

Estrogen/Estrogen Receptor Alpha Signaling in Mouse Posterofrontal Cranial Suture Fusion
por: James, Aaron W., et al.
Publicado: (2009)

The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer
por: Allred, D Craig, et al.
Publicado: (2004)

Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial Function
por: Yoh, Kenta, et al.
Publicado: (2023)

Structure-activity relationships of estrogens.
por: Jordan, V C, et al.
Publicado: (1985)

Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer
por: Mayne, Christopher G., et al.
Publicado: (2021)

Estrogen-repressed genes – key mediators of estrogen action?
por: Zubairy, Simeen, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_1inu2uudfaqlgvghflorbr3t0j