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Redesigning TOR Kinase to Explore the Structural Basis for TORC1 and TORC2 Assembly
TOR is a serine/threonine protein kinase that assembles into distinct TOR Complexes 1 and 2 (TORC1 or TORC2) to regulate cell growth. In mammalian cells, a single mTOR incorporates stably into mTORC1 and mTORC2. By contrast, in Saccharomyces cerevisiae, two highly similar Tor1 and Tor2 proteins exis...
Autores principales: | Hill, Andrew, Niles, Brad, Cuyegkeng, Andrew, Powers, Ted |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023025/ https://www.ncbi.nlm.nih.gov/pubmed/29865216 http://dx.doi.org/10.3390/biom8020036 |
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