Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV

HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know little about the fitness costs of individual HIV mutations in vivo, their distribution and the different factors shaping the viral fitness landscape. We calculated the mean frequency of transition muta...

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Detalles Bibliográficos
Autores principales: Theys, Kristof, Feder, Alison F., Gelbart, Maoz, Hartl, Marion, Stern, Adi, Pennings, Pleuni S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023119/
https://www.ncbi.nlm.nih.gov/pubmed/29953449
http://dx.doi.org/10.1371/journal.pgen.1007420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023119/
https://www.ncbi.nlm.nih.gov/pubmed/29953449
http://dx.doi.org/10.1371/journal.pgen.1007420

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